Endocrine Abstracts

Pancreatic neuroendocrine tumours (PNETs) have a lower mutational burden than other tumours, indicating that other mechanisms contribute to tumourigenesis. One such reported mechanism is DNA methylome dysregulation, however, inconsistencies have been observed between gene methylation and protein expression, potentially stemming from the use of standard methylation assessment methods which do not distinguish methylation (5’methylcytosine (5’mC), repressive mark) from ...

Hypothalamic–pituitary–adrenal (HPA) axis function after trans-sphenoidal pituitary surgery is commonly assessed using post-operative morning cortisol. We performed a prospective study to determine the sensitivity and specificity of cortisol and ACTH measured within the first 24 h, in predicting glucocorticoid requirement at 6 months both in patients with pre-operative secondary adrenal insufficiency (SAI) and with normal pituitary function. Exclusion criteria includ...

Neuroendocrine tumours (NETs) presenting as metastatic cancer of unknown primary site (CUP) are suspected to confer poorer prognosis compared to metastatic NETs of known primary site. We performed a retrospective, single centre study to determine the prognostic indicators in CUP-NETs compared to metastatic small intestinal NET (SiNET), before and after adjusting for factors known to affect overall survival. Subjects were selected from a departmental database of 1050 NET patien...